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Background
Immunology has become one of the most important areas of research in medicine. It broadly overlaps nearly every specialty. The diagnostic pathologist has always been interested in adopting the latest immunological discoveries to practical diagnostic testing. Some of the areas where these principles have been applied include transfusion medicine with cross matching and identification of alloantibodies, serology and identification of serum markers for disease, and molecular biology with identification of key regulatory steps in cell biology.
Cytokines
Molecular Biology
Serology
Transfusion MedicineOUTLINE
Laboratory/Radiologic/Other Diagnostic Testing Commonly Used Terms Internet Links
LABORATORY/RADIOLOGIC/
OTHER TESTSCHARACTERIZATION RADIOLOGIC LABORATORY MARKERS FLOW CYTOMETRY
Current applications of flow cytometry in the diagnosis of primary immunodeficiency diseases.
Illoh OC.
Department of Pathology, University of Virginia Health System, Charlottesville 22908, USA.
Arch Pathol Lab Med. 2004 Jan;128(1):23-31. Abstract quote
CONTEXT: To review the applications of flow cytometry in the diagnosis and management of primary immunodeficiency disease.
DATA SOURCES: Articles describing the use of flow cytometry in the diagnosis of several primary immunodeficiency diseases were obtained through the National Library of Medicine database.
STUDY SELECTION: Publications that described novel and known applications of flow cytometry in primary immunodeficiency disease were selected. Review articles were included. Articles describing the different immunodeficiency diseases and methods of diagnosis were also selected.
DATA EXTRACTION: Approximately 100 data sources were analyzed, and those with the most relevant information were selected.
DATA SYNTHESIS: The diagnosis of many primary immunodeficiency diseases requires the use of several laboratory tests. Flow cytometry has become an important part of the workup of individuals suspected to have such a disorder. Knowledge of the pathogenesis of many of these diseases continues to increase, hence we acquire a better understanding of the laboratory tests that may be helpful in diagnosis.
CONCLUSIONS: Flow cytometry is applicable in the initial workup and subsequent management of several primary immunodeficiency diseases. As our understanding of the pathogenesis and management of these diseases increases, the use of many of these assays may become routine in hospitals.Henry JB. Clinical Diagnosis and Management by Laboratory Methods. Twentieth Edition. WB Saunders. 2001.
Rosai J. Ackerman's Surgical Pathology. Eight Edition. Mosby 1996.
Sternberg S. Diagnostic Surgical Pathology. Third Edition. Lipincott Williams and Wilkins 1999.
Robbins Pathologic Basis of Disease. Sixth Edition. WB Saunders 1999.
DeMay RM. The Art and Science of Cytopathology. Volume 1 and 2. ASCP Press. 1996.
Weedon D. Weedon's Skin Pathology Second Edition. Churchill Livingstone. 2002
Fitzpatrick's Dermatology in General Medicine. 5th Edition. McGraw-Hill. 1999.
Weiss SW and Goldblum JR. Enzinger and Weiss's Soft Tissue Tumors. Fourth Edition. Mosby 2001.
Basic Principles of Disease
Learn the basic disease classifications of cancers, infections, and inflammation
Commonly Used Terms
This is a glossary of terms often found in a pathology report.Diagnostic Process
Learn how a pathologist makes a diagnosis using a microscopeSurgical Pathology Report
Examine an actual biopsy report to understand what each section meansSpecial Stains
Understand the tools the pathologist utilizes to aid in the diagnosisHow Accurate is My Report?
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Last Updated 1/9/2004
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