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This is a 29 year old man with a several month history of weight loss and diarrhea. The biopsy is from the duodenum.

Microscopic Findings


Sections show a relatively preserved crypt-to-villous ratio, with no evidence of atrophy.

  Figure 1      


The lamina propria shows an increase in cellularity, populated by a mononuclear cell infiltrate of lymphocytes and plasma cells.

No significant architectural distortion of the glands or crypts are noted.

  Figure 2      

    Many of the villi contain an increase in intraepithelial lymphocytes, extending through the full length of the villi and numbering over 1 lymphocyte per 3-4 enterocytes.  
  Figure 3      



Another view of the increased intraepithelial lymphocytes.

  Figure 4      

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Last Updated 11/4/2002

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