Home Translating Report News Physicians Diseases Body Sites Lab tests Search
Home Diseases and Health Information

Diagnosis

Sclerosing Angiomatoid Nodular Transformation of the spleen (SANT)

Discussion

This is a rare but benign disease that is often an incidental finding or may present with abdominal pain or discomfort and splenic enlargement. The mean age is 48.4 years with a predominance of cases occurring in women. Examination of the spleen reveals a solitary nodule that can vary from 3-17 cm that is demarcated from the surrounding spleen. Microscopic evaluation reveals multiple nodules composed of vascular slit-like spaces and lined by plump endothelial cells. There may be broad bands of hyalinization or concentric rings of collagen encircling some of the nodules. The nodules contain numerous extravasated red blood cells and chronic inflammatory cells. Immunohistochemical analysis suggests these nodules are derived from red pulp. It is hypothesized that these nodules represent red pulp entrapped by a nonneoplastic stromal proliferation. The lesion is benign.

References

Am J Surg Pathol 2004;28:1268-1279.


Commonly Used Terms

Basic Principles of Disease
Learn the basic disease classifications of cancers, infections, and inflammation

Commonly Used Terms
This is a glossary of terms often found in a pathology report.

Diagnostic Process
Learn how a pathologist makes a diagnosis using a microscope

Surgical Pathology Report
Examine an actual biopsy report to understand what each section means

Special Stains
Understand the tools the pathologist utilizes to aid in the diagnosis

How Accurate is My Report?
Pathologists actively oversee every area of the laboratory to ensure your report is accurate

Got Path?
Recent teaching cases and lectures presented in conferences


Internet Links

Last Updated October 27, 2004

Send mail to The Doctor's Doctor with questions or comments about this web site.
Copyright © 2004 The Doctor's Doctor