Background
Molluscum contagiosum (MC) is a very common viral infection. It produces dome shaped flesh colored papules measuring 2-5 mm in diameter. It is caused by the Molluscum contagiosum virus and is prevalent in sexually active adults, young children, and immunocompromised patients. The lesions may persist for weeks to months suggesting the virus provokes a minimal cell-mediated immunity.
OUTLINE
EPIDEMIOLOGY CHARACTERIZATION AGE
J Am Acad Dermatol. 2006 Jan;54(1):47-54. Epub 2005 Nov 21. Abstract quote
Molluscum contagiosum (MC) is a viral disorder of the skin and mucous membranes characterized by discrete single or multiple, flesh-colored papules. Although MC as a clinical entity is well defined and commonly observed, few data regarding its epidemiology in the pediatric population exist.
Our purpose was to collect epidemiologic data on children with MC with regard to age, gender, ethnicity, degree of involvement, relation to pre-existing atopic dermatitis (AD), and immune status. A retrospective chart review was conducted. All subjects were seen at 3 tertiary pediatric dermatology referral centers with two of the sites based at a Children's Hospital. A total of 302 patient charts with the Current Procedural Terminology code diagnosis of MC seen over a 6- to 8-month period were reviewed. Approximately 80% of the patients were younger than 8 years old. The majority of patients (63%) had more than 15 lesions. All but one patient were otherwise healthy, as determined by history and clinical examination. Approximately 24% of the patients presented with a history of previous or active coexistent AD. However, children with AD were at risk for an increased number of lesions.
These data provide valuable updated information on the demographics and clinical presentation of MC in pediatric patients in the United States. Limitations include that this was a retrospective study with a population limited to tertiary pediatric dermatology referral centers.INCIDENCE
Molluscum contagiosum virus: antibody responses in persons with clinical lesions and seroepidemiology in a representative Australian population.Konya J, Thompson CH.
Department of Infectious Diseases, Faculty of Medicine, University of Sydney, Sydney, New South Wales 2006, Australia.
J Infect Dis 1999 Mar;179(3):701-4 Abstract quote An ELISA for molluscum contagiosum virus (MCV) was used to determine the antibody status of 35 adults with clinical infections and known human immunodeficiency virus (HIV) serology and of 357 persons (ages, 1 week-69 years) considered representative of the Australian population. MCV antibody was identified in 77% of persons with molluscum lesions: in 17 of 24 HIV-1-negative persons and in 10 of 11 who were HIV-1-positive. No relationship was evident between the serologic responses and the number of lesions or the duration of infection.
The population survey revealed an overall seropositivity rate of 23%. The lowest antibody prevalence was in children aged 6 months to 2 years (3%), and seropositivity increased with age to reach 39% in persons >/=50 years old.
These findings indicate that MCV infections, including very mild or subclinical cases, may be more common in the general community than previously suspected.
DISEASE ASSOCIATIONS CHARACTERIZATION AIDS Int J Dermatol 1994;33:453-461
5-18% of patientsAXILLARY GRANULAR PARAKERATOSIS
- Incidental Granular Parakeratosis Associated With Molluscum Contagiosum.
Pock L, Cermakova A, Zipfelova J, Hercogova J.
From the *Dermatopathologic Laboratory, 2nd Medical Faculty, Charles University, Prague, Czech Republic; daggerDepartment of Dermatology, Znojmo; double daggerDepartment of Dermatology, Moravsky Krumlov; and section signDepartment of Dermatology and Venereology, 2nd Medical Faculty, Charles University, Prague, Czech Republic.
Am J Dermatopathol. 2006 Feb;28(1):45-47. Abstract quote
A patient presented with a 4-month history of slowly progressive pruritic papules on her trunk and extremities.
Biopsies from 2 of these lesions revealed molluscum contagiosum. One of the biopsies also showed several small foci of granular parakeratosis.
Based on the clinical features and course of this patient, the granular parakeratosis seems to be an incidental finding.
TREATMENT CHARACTERIZATION Canthardin for treatement of childhood molluscum contagiosum
Silverberg, Sidbury, and Mancini
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Last Updated February 22, 2006
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