Background
Tubular carcinoma of the breast is a well-differentiated variant of invasive ductal carcinoma and has been shown to have an exceptionally favorable prognosis.
OUTLINE
Pathogenesis Gross Appearance and Clinical Variants Histopathological Features and Variants Prognosis Treatment Commonly Used Terms Internet Links
TREATMENT AND PROGNOSIS PROGNOSIS Well-differentiated (tubular) carcinoma of the breast. A clinicopathologic study of 145 pure and mixed cases.
Deos PH, Norris HJ.
Am J Clin Pathol 1982 Jul;78(1):1-7 Abstract quote
In this study, 145 well-differentiated (tubular) carcinomas were divided into two groups: 90 pure tubular carcinomas and 55 which were mixtures in that they contained a component of infiltrating duct carcinoma occupying less than half the tumor.
Axillary lymph node metastases developed in 29% of women in the mixed group, but occurred in only 6% of the pure group. The prognosis was good in both groups, with five-year-actuarial survival rates in the pure and mixed groups of 100% and 93%, respectively. Residual carcinoma was present in the mastectomy specimen in 28% of the pure group, and in 40% of the mixed carcinomas. In addition, there was a recurrence rate of 50% in patients with pure tubular carcinoma treated by excisional biopsy.
These features indicate simple excision of tubular carcinoma is likely to be inadequate therapy and that a mastectomy is warranted. Axillary node dissections should be done when there is a component of infiltrating duct carcinoma because of the increased risk of axillary lymph node metastasis.
Tubular carcinoma of the breast. Clinical and pathological observations concerning 135 cases.
McDivitt RW, Boyce W, Gersell D.
Am J Surg Pathol 1982 Jul;6(5):401-11 Abstract quote
Clinical and pathological features of 135 tubular carcinomas are discussed.
Tumor size varied from 0.2 to 2.5 cm with a mean diameter of 0.9 cm. In situ carcinoma was found associated with tubular cancer in 86 cases (63.6%). In 82 of 86 (95.3%) it was of micropapillary/cribriform intraductal type. Twelve of 109 patients in whom axillary dissection was performed were found to have axillary metastases. Six patients (4%) developed recurrent or disseminated metastatic carcinoma during a mean follow-up period of 7.2 years. Two of these patients are dead of disease.
Tubular carcinoma should be distinguished from microglandular adenosis, an uncommon form of sclerosing adenosis.
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Last Updated December 9, 2004
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