Background
These rare tumors arise from skin sweat glands. They characteristically occur on the hands, fingers, and toes. They occur predominately in men with a mean age of 52 yrs (19-83 yrs). They average 1.7 cm in size and may be present for 2 months to 15 years with a mean of 29 months. Pain is a frequent presenting complaint. When these tumors were first described, they were divided into an aggressive digital papillary adenoma and a carcinoma. Subsequent follow-up of lesions designated as adenomas found a metastatic potential of 14%. Thus all of these tumors are more correctly classified as carcinomas with no benign counterpart. No consistent microscopic feature has been found which separates benign behaving tumors from those with local recurrence or metastasis.
Under the microscope, these tumor are multinodular, solid, and cystic with papillary projections. Occasional connection to the overlying epidermis is present. A characteristic pattern is fused back-to-back glands lined by cuboidal to low columnar cells. Circumscription with hyalinized stroma is present in some cases. Necrosis is present in about half of the cases. Cytologic atypia is mild to occasionally moderate. The mitotic rate ranges from 0-60 per 10 hpf with a mean of 17.
The prognosis of these tumors is guarded. In the cases of metastasis, two had been treated with re-excision or amputation and had metastasis at the time of their initial presentation. Two others developed metastasis without local recurrence and two patients not treated with re-excision or amputation within 6 months of initial presentation developed subsequent metastasis with local recurrence. A complete excision is recommended since there is a 50% local recurrence rate in patients who do not receive treatment.
OUTLINE
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