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Background

These are malignant tumors of the salivary glands that are dervied from the salivary gland epithelium and characteristically forms glandular acini. It is notable for an unpredictable clinical course with both local recurrence and distant metastases. The vast majority (83%) occur within the parotid gland, usually as a slowly enlarging mass. Pain or tenderness may be present in up to 1/3 of patients.

OUTLINE

Epidemiology  
Disease Associations  
Pathogenesis  
Laboratory/Radiologic/Other Diagnostic Testing  
Gross Appearance and Clinical Variants  
Histopathological Features and Variants  
Special Stains/
Immunohistochemistry/
Electron Microscopy
 
Differential Diagnosis  
Prognosis  
Treatment  
Commonly Used Terms  
Internet Links  

EPIDEMIOLOGY CHARACTERIZATION
INCIDENCE 3rd most common epithelial malignancy of the salivary gland
17% of all primary salivary gland malignancies
6% of salivary gland neoplasms
AGE RANGE-MEDIAN Mean age is 44 years
12% of patients < 20 years
SEX (M:F)
2:3
GEOGRAPHY
No racial predilection

 

DISEASE ASSOCIATION CHARACTERIZATION
RADIATION

Acinic cell carcinoma: its occurrence in the laryngotracheal junction after thyroid radiation.

Squires JE, Mills SE, Cooper PH, Innes DJ Jr, McLean WC.

Arch Pathol Lab Med 1981 May;105(5):266-8 Abstract quote

An acinic cell carcinoma of the laryngotracheal junction developed in a 54-year-old woman 46 years after administration of radiation to her thyroid gland. Although salivary gland neoplasia has been associated with a history of radiation therapy during childhood, acinic cell carcinoma in such a setting is rare. In addition, she had parathyroid hyperplasia and multiple thyroid adenomas, lesions that have been associated with prior administration of radiation.

A history of exposure to radiation should be sought in patients with salivary gland neoplasms of the larynx or trachea.

 

PATHOGENESIS CHARACTERIZATION
CHROMOSOMAL ABNORMALITIES

Genetic alterations in acinic cell carcinoma of the parotid gland determined by microsatellite analysis.

el-Naggar AK, Abdul-Karim FW, Hurr K, Callender D, Luna MA, Batsakis JG.

Department of Pathology, University of Texas, M. D. Anderson Cancer Center, Houston 77030, USA.

Cancer Genet Cytogenet 1998 Apr 1;102(1):19-24 Abstract quote

We investigated, for the first time, the genetic alterations at certain chromosomal loci in 25 primary parotid acinic cell carcinomas to define the most frequently altered chromosomal regions and their association with pathologic features and DNA content analysis.

Our results showed that 21 (84.0%) of the tumors had alteration in at least one of the loci tested. In general, chromosomal regions at chromosomes 4p, 5q, 6p, and 17p were more frequently altered than those on chromosomes 1p and 1q, 4q, 5p, and 6q. Certain markers at 4p15-16, 6p25-qter, and 17p11 regions showed the highest incidence of LOH, suggesting the presence of tumor suppressor genes associated with the oncogenesis of these tumors. LOH was significantly associated only with tumor grade. No apparent correlation between LOH and other clinicopathologic and DNA content characteristics was identified.

Our study broadly defined the chromosomal arms and loci that may be targeted for further localization of the minimally deleted regions involved in the tumorigenesis of these tumors.

RETINOBLASTOMA GENE PATHWAYS  

Abnormal expression of Rb pathway-related proteins in salivary gland acinic cell carcinoma.

Liu T, Zhu E, Wang L, Okada T, Yamaguchi A, Okada N.

Section of Oral Pathology, Graduate School of Tokyo Medical and Dental University, Tokyo 113-8549, Japan; Section of Oral Pathology, Dental School, Dalian Medical University, Dalian 116027, China.

Hum Pathol. 2005 Sep;36(9):962-70. Abstract quote  

Salivary gland acinic cell carcinoma (ACC) is a relatively rare neoplasm, and limited information is available regarding its molecular pathogenesis. Because the deregulation of Rb pathway is common to most human tumors, we immunohistochemically investigated the expression of Rb pathway-related proteins, including Rb, Rb proteins phosphorylated at serine 780 and 795 (pRb-S780 and pRb-S795, respectively), cyclin D1, and p16(INK4a) in 18 cases of ACC. The expression of topoisomerase II-alpha and Ki-67 was also examined to evaluate cell proliferation.

All the ACCs exhibited substantial numbers of positive cells against Rb antibody that recognizes both unphosphorylated and phosphorylated Rb proteins. The numbers of positive cells for pRb-S795 and cyclin D1 significantly increased in ACCs as compared with normal salivary glands. Double immunofluorescent staining demonstrated that pRb-S795 was colocalized with cyclin D1 in most tumor cells. However, neither significant change of the expression of Rb protein phosphorylated at serine 780 nor its colocalization with cyclin D1 was observed. The loss of p16(INK4a) is infrequent, but its expression was correlated with phosphorylated Rb proteins.

Our results suggest that serine 795 but not serine 780 is the preferred phosphorylation site induced by cyclin D1. This phosphorylation appeared to be critical for inactivation of Rb-mediated growth suppression and may play an important role in the pathogenesis of ACC.

 

GROSS APPEARANCE/
CLINICAL VARIANTS
CHARACTERIZATION
General Single well circumscribed tumors
1-3 cm
Lobular tan to reddish surface
Solid to cystic
VARIANTS  
FAMILIAL  

Familial occurrence of acinic cell carcinoma of the parotid gland.

Depowski PL, Setzen G, Chui A, Koltai PJ, Dollar J, Ross JS.

Department of Pathology, Albany Medical College, NY 12208, USA.

Arch Pathol Lab Med 1999 Nov;123(11):1118-20 Abstract quote

We report the familial occurrence of acinic cell carcinoma involving the parotid gland, the first such report of which we are aware. The familial occurrence of any salivary gland neoplasm is rare. Several reports are present in the literature, including pleomorphic adenoma, Warthin tumor, carcinoma of the submandibular gland, and malignant lymphoepithelial lesion.

We report the case of a 35-year-old man who underwent excision of a left parotid gland acinic cell carcinoma. Eight years later, his daughter presented at the age of 16 years with a nontender parotid gland mass that was excised and found also to be acinic cell carcinoma. The histologic features of both neoplasms were typical of acinic cell carcinoma.

hile this may represent a coincidental event, the possibility that this familial occurrence is a manifestation of common genetic or environmental risk cannot be excluded.

PEDIATRIC  

Acinic cell carcinoma of the parotid gland in childhood.

Tucci FM, Bianchi PM, Bottero S, Partipilo P, Pierro V.

Bambino Gesu Children's Hospital, ENT Department, Roma, Italy

Int J Pediatr Otorhinolaryngol 1993 Aug;27(2):187-91 Abstract quote

A 13-year-old girl underwent surgery at the Ear Nose and Throat Department of the Children's Hospital and Scientific Research Institute, Bambino Gesu, Rome, because of an acinic cell carcinoma of the parotid gland.

Two years after total parotidectomy with preservation of the facial nerve, metastasis occurred in a lateral cervical lymph node. Acinic cell tumors are uncommon in childhood; in children under the age of 16 years only 35 cases have been reported. There are too few acinar cell carcinomas occurring in children to yield an idea of their natural course. The neoplasm is also referred to as 'acinar cell tumor', in contrast to acinar cell carcinoma, because the neoplasm may be benign or malignant.

Unfortunately, there are no histological distinguishing features that permit the pathologist to determine which neoplasm will behave in an aggressive fashion.

Synchronous or metachronous 3% of cases are bilateral

 

HISTOLOGICAL TYPES CHARACTERIZATION
General

Sheets of polygonal cells with granular, lightly basophilic cytoplasm and uniform nuclei resembling serous acinar cells
May be separated by thin fibrovascular septa

Vacuolated cells characteristic
Clear cells may be abundant

Usually infiltrate surrounding tissue

VARIANTS  
DEDIFFERENTIATED  

Dedifferentiated acinic cell carcinoma of the parotid gland: a distinct rarely described entity.

Henley JD, Geary WA, Jackson CL, Wu CD, Gnepp DR.

Department of Pathology, Rhode Island Hospital and Brown University School of Medicine, Providence 02903, USA.

Hum Pathol 1997 Jul;28(7):869-73 Abstract quote

A case of dedifferentiated acinic cell carcinoma of the parotid gland is presented. A 46-year-old man presented with a parotid gland mass. At surgery the tumor was found adherent to the temporal bone and cervical adenopathy was present. Treatment included radical parotidectomy and intraoperative radiotherapy.

Histologically, the tumor was a composite of a usual low-grade acinic cell carcinoma and high-grade, poorly differentiated carcinoma. Cervical lymph node metastases were composed entirely of high-grade carcinoma. Immunohistochemically, both low- and high-grade malignant components were negative for p53 oncoprotein expression.

Moreover, polymerase chain reaction and nonisotopic single-stranded conformational polymorphism analyses were consistent with a germ line configuration of the p53 gene, exons five through eight, in both low- and high-grade elements of the tumor. The literature on this unusual variant of acinic cell carcinoma is reviewed.

Dedifferentiated acinic cell carcinoma of the parotid gland with myoepithelial features.

Piana S, Cavazza A, Pedroni C, Scotti R, Serra L, Gardini G.

Department of Clinical Pathology, Division of Anatomic Pathology (Drs Piana, Cavazza, Scotti, Serra, and Gardini), and the Department of Otolaryngology (Dr Pedroni), Ospedale Santa Maria Nuova, Reggio Emilia, Italy.

Arch Pathol Lab Med 2002 Sep;126(9):1104-5 Abstract quote

Dedifferentiated acinic cell carcinoma of the salivary gland is an uncommon variant of acinic cell carcinoma, characterized by the coexistence of both an usual low-grade acinic cell carcinoma and a high-grade dedifferentiated component, as well as by an accelerated clinical course.

We describe a case of acinic cell carcinoma of the parotid gland in a 67-year-old woman, which recurred 4 times after surgery and radiotherapy. The recurrences consisted of residual foci of acinic cell carcinoma intermingled with a high-grade epithelial proliferation; the latter was focally constituted by cells with morphologic and immunohistochemical features of myoepithelium.

Follicular
Multiple cystic lumens filled with eosinophilic proteinaceous material, resembling thyroid follicles
Microcystic
 
Papillocystic

In rare cases, the tumor may dedifferentiate resulting in areas of poorly differentiated or undifferentiated carcinoma.

Hemorrhage more common with this type

Solid Acinar
 

 

SPECIAL STAINS/
IMMUNOPEROXIDASE
CHARACTERIZATION
SPECIAL STAINS Granules PAS positive, diastase resistant
IMMUNOPEROXIDASE Cytokeratin, transferrin, CD15, CEA
Some positive for S100 and GFAP
Differential diagnosis of salivary acinic cell carcinoma and adenocarcinoma (NOS). A comparison of (immuno-)histochemical markers.

Ihrler S, Blasenbreu-Vogt S, Sendelhofert A, Lang S, Zietz C, Lohrs U.

Institute of Pathology, Ludwig-Maximilians-University, Munich, Germany.
Pathol Res Pract. 2002;198(12):777-83. Abstract quote  

A correct histologic differential diagnosis between salivary acinic cell carcinoma (ACC) and adenocarcinoma not otherwise specified (AC-NOS) is highly relevant because of the strikingly different biologic behavior and related therapeutical strategies. The distinction between both tumor types can be difficult because of an enormous variation in histologic appearance, with either type showing partially overlapping morphologic features.

Owing to a lack of approved markers, the expression of PAS-staining, alpha-Amylase, alpha-1 Anti-trypsin, cytokeratin (CK)-subtypes 7/18 and Ki-67 was evaluated in 16 cases of ACC and 16 cases of AC-NOS. CK 7 is identified as the most reliable marker with strong positivity in AC-NOS, and complete or preponderant negativity in ACC.

The characteristic membranous staining pattern of CK 18 in ACC, in contrast to a diffuse cytoplasmic pattern in AC-NOS, proved to be an additional valuable criterion. PAS and alpha-Amylase are only of little value when ACC is diagnosed, as many cases are only faintly positive or completely negative. The proliferation index (Ki-67) proved to be significantly higher in AC-NOS; however, the diagnostic usefulness is limited by a relevant overlap.

In conclusion, we recommend CK 7 and 18 as the most valuable markers in cases with difficult differential diagnosis between ACC and AC-NOS.
Electron microscopy (EM) Multiple round electron dense secretory granules

Some ultrastructural features of acinic cell carcinoma.

Bloom GD, Carlsoo B, Henriksson R.

J Laryngol Otol 1977 Nov;91(11):947-958 Abstract quote

The ultrastructure of an acinic cell carcinoma, occurring in the left parotid gland of a 52-year-old woman and causing a total facial nerve paralysis, is described.

Histologically the tumour consisted of numerous granulated cells arranged around lumen-like openings and resembling a secretory system. Furthermore, areas with agranulated cells growing in a solid pattern were also encountered.

In the electron microscope the cytoplasmic granules of the tumour cells displayed a varied appearance. Granules of a dense homogeneous type, as well as granules with a more electron lucid appearance were observed. Furthermore, numerous cytoplasmic granules displayed a bipartite structure with a dense central and a more electron lucid outer zone. In specimens primarily fixed in OSO4 or KMnO4 the granules displayed a 'leached out' appearance.

The membrane-bounded of the tumour cells also showed a strong positive staining with the periodic acid-chromic silver technique of Rambourg et al. (1969). Other characteristic ultrastructural features of the tumour cells studied were: Smooth cell surfaces, the presence of subplasmalemmal bands of electron dense material, desmosome-like attachment areas between cells and grossly altered mitochondria.

 

DIFFERENTIAL DIAGNOSIS KEY DIFFERENTIATING FEATURES
Cystadenocarcinoma  
Mucoepidermoid carcinoma  
Metastatic thyroid papillary carcinoma  
Polymorphous low-grade adenocarcinoma  
Epithelial-myoepithelial carcinoma  
Clear cell adenocarcinoma  
Clear cell oncocytoma  
Metastatic renal cell carcinoma  

 

PROGNOSIS AND TREATMENT CHARACTERIZATION
PROGNOSIS Poor factors include:

Short duration of symptoms
Incomplete excision
Frequent mitoses
Focal necrosis
Neural invasion
Pleomorphism
Infiltration
Stromal hyalinization
Large size
Involvement of the deep lobe of the parotid gland
GENERAL  

Acinic cell carcinoma in Northern Ireland: a 10-year review.

Napier SS, Herron BT, Herron BM.

Division of Dental Surgery and Pathology, School of Clinical Dentistry, Queen's University, Belfast.

Br J Oral Maxillofac Surg 1995 Jun;33(3):145-8 Abstract quote

12 cases of acinic cell carcinoma diagnosed in Northern Ireland from 1942 to 1982 on which there was at least 10 years' follow-up were reviewed, by pooling cases from all regional pathology laboratories.

Clinical findings at presentation were established from case notes, together with details of eventual clinical outcome. Sections were examined to determine tumour size, morphological pattern and cytological constitution, the presence or absence of cytological atypia, mitotic activity, lymphocytic and desmoplastic responses, and to assess for infiltrative margins and adequacy of excision. The tumours arose in 8 females and 4 males, aged 22 to 86 years at presentation. Eleven tumours were in the parotid, one in the soft palate. Two patients suffered local recurrence, both more than 7 years after diagnosis. Five patients had regional lymph node metastasis, four at presentation. No patient suffered haematogenous metastasis or died of tumour. Of the features examined, incomplete excision increased the risk of local recurrence.

While numbers are small, the acinic cell carcinoma in Northern Ireland is an unpredictable low-grade malignant tumour which is capable of recurrence and metastasis. Adequate excision at presentation appears to be the most appropriate therapy.

Clinico-pathological predictors of recurrence for acinic cell carcinoma.

Timon CI, Dardick I, Panzarella T, Thomas J, Ellis G, Gullane P.

Department of Otolaryngology, Head and Neck Surgery, Toronto Hospital, Ottawa, Canada.

Clin Otolaryngol 1995 Oct;20(5):396-401 Abstract quote

The biological behaviour of acinic cell carcinomas, even if well differentiated, is unpredictable. We studied 45 patients with acinic cell carcinoma followed-up from 10 to 379 months (5 year recurrence-free and survival rate of 69% and 81% respectively), and compared clinico-pathological parameters with outcome.

The presence of a predominately solid architecture was strongly associated with a poor outcome (P < 0.01) and this was the only independent prognostic variable when log rank testing was performed.

Tumour size (> 2.75 cm) was a significant predictor of recurrent deep parotid lobe involvement, the presence of cervical nodal disease and lymphocytic infiltration, although not significant, factors showed a tendency towards recurrence. For acinic cell carcinoma, the predominant solid architecture would appear to be a strong predictor of recurrence.

PLOIDY ANALYSIS  

Acinic cell carcinoma of the salivary glands: the prognostic relevance of DNA cytophotometry in a retrospective study of long duration (1965-1987).

Hamper K, Mausch HE, Caselitz J, Arps H, Berger J, Askensten U, Auer G, Seifert G.

Institute of Pathology, University-Hospital Hamburg-Eppendorf, West Germany.

Oral Surg Oral Med Oral Pathol 1990 Jan;69(1):68-75 Abstract quote

Acinic cell carcinomas of the Salivary Gland Registry, Institute of Pathology, University of Hamburg, West Germany, from 1965 to 1980 (n = 55) were evaluated retrospectively with respect to histologic, cytophotometric, and clinical data.

The majority of the tumors (92.8%) were located in the parotid gland. Two thirds of the patients were female; one third were male. Mean age at primary diagnosis was 55.4 years. The tumors were graded into highly differentiated (76%) or less differentiated forms (24%) according to classic histologic and cytologic criteria. The clinical course was characterized by no recurrence in 15 cases; in 17 cases, recurrences developed, and 12 patients died of their tumor, some as late as 240 months after primary diagnosis. Differentiation showed a weak correlation with the clinical course. In 35 cases, nuclear DNA content of tumor cells was assessed cytochemically.

The tumors were "diploid" or "near-diploid" in 34 cases; DNA content showed no correlation to the clinical course. As a result of long-term follow-up, it becomes evident that acinic cell carcinoma is prone to develop recurrences and metastases.

Complete tumor removal during the primary operation seems to be important for controlling the disease inasmuch as the ostensible prognostic predictors evaluated here proved to be unreliable.

DNA flow cytometry of acinic cell carcinomas of major salivary glands.

el-Naggar AK, Batsakis JG, Luna MA, McLemore D, Byers RM.

Department of Pathology, University of Texas MD Anderson Cancer Center, Houston.

J Laryngol Otol 1990 May;104(5):410-6 Abstract quote

Fifteen acinic cell carcinomas from an equal number of patients were analysed for their DNA content and proliferative (S-phase) index by flow cytometry from archival tissues. Seven of the carcinomas manifested a diploid DNA content.

None of the patients with diploid acinic cell carcinomas died of their carcinomas and none developed metastases in follow-up periods extending for 10 or more years. Four of eight patients with aneuploid acinic cell carcinomas have died because of their malignancies within a 10 year period after the first surgical removal of the carcinoma. Five of the eight patients exhibited metastases.

Although the number of cases does not permit strong correlations between histopathological features, abnormalities in DNA content and outcome of patients, it was noted that carcinomas with prominent necrosis, tubuloductal differentiation and 'dedifferentiated' areas displayed more aggressive biological courses.

Survival About 16% die from the tumor
Recurrence 35%
Usually within first 5 years after resection of the primary tumor
METASTATIC  
Widespread cutaneous metastases from acinic cell carcinoma 20 years after primary presentation.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

J Cutan Pathol. 2008 Jun;35(6):591-3. Abstract quote

Acinic cell carcinoma is a rare, low-grade malignant salivary gland neoplasm. Approximately, 20% of patients experience local recurrence and 10% distant metastasis, often many years after initial presentation.

We present a case of widespread cutaneous metastasis from acinic cell carcinoma arising in a 59-year-old woman with a history of acinic cell carcinoma of the parotid gland 20 years prior to her cutaneous disease.

To our knowledge, is the first report of widespread cutaneous metastasis from acinic cell carcinoma.

Acinic cell carcinoma of salivary origin. A clinicopathologic study of 67 cases.

Spiro RH, Huvos AG, Strong EW.

Cancer 1978 Mar;41(3):924-35 Abstract quote

This study reviews a 30 year experience with acinic cell carcinoma.

The tumor arose in the parotid gland in 64 patients, the submaxillary gland in one and minor salivary glands in two. In untreated patients with small tumors, clinical findings usually suggested a benign mixed tumor and a subtotal parotidectomy which spared the facial nerve was highly effective therapy.

In contrast, local recurrence and death was the rule in those few who had locally extensive disease, regardless of how radical an operation was performed. Determine "cure" rates for the entire group were 76, 63 and 55% at 5, 10 and 15 years, respectively. Cervical lymph node metastasis occurred in 16% of the patients, and distant metastasis in 12%.

Survival was most directly influenced by the clinical extent of the primary tumor, and also correlated with certain histologic features which are described.

Acinic cell carcinoma of the salivary glands: the prognostic relevance of DNA cytophotometry in a retrospective study of long duration (1965-1987).

Hamper K, Mausch HE, Caselitz J, Arps H, Berger J, Askensten U, Auer G, Seifert G.

Institute of Pathology, University-Hospital Hamburg-Eppendorf, West Germany.

Oral Surg Oral Med Oral Pathol 1990 Jan;69(1):68-75 Abstract quote

Acinic cell carcinomas of the Salivary Gland Registry, Institute of Pathology, University of Hamburg, West Germany, from 1965 to 1980 (n = 55) were evaluated retrospectively with respect to histologic, cytophotometric, and clinical data.

The majority of the tumors (92.8%) were located in the parotid gland. Two thirds of the patients were female; one third were male. Mean age at primary diagnosis was 55.4 years. The tumors were graded into highly differentiated (76%) or less differentiated forms (24%) according to classic histologic and cytologic criteria. The clinical course was characterized by no recurrence in 15 cases; in 17 cases, recurrences developed, and 12 patients died of their tumor, some as late as 240 months after primary diagnosis. Differentiation showed a weak correlation with the clinical course. In 35 cases, nuclear DNA content of tumor cells was assessed cytochemically. The tumors were "diploid" or "near-diploid" in 34 cases; DNA content showed no correlation to the clinical course.

As a result of long-term follow-up, it becomes evident that acinic cell carcinoma is prone to develop recurrences and metastases. Complete tumor removal during the primary operation seems to be important for controlling the disease inasmuch as the ostensible prognostic predictors evaluated here proved to be unreliable.

TREATMENT Complete surgical excision
  Radiation may improve survival in patients for whom complete excision cannot be achieved

Acinic cell carcinoma of the salivary glands. A long term follow-up study of 15 cases.

Oliveira P, Fonseca I, Soares J.

Servico de Patologia Morfologica, Instituto Portugues de Oncologia de Francisco Gentil-Centro de Lisboa.

Eur J Surg Oncol 1992 Feb;18(1):7-15 Abstract quote

Fifteen cases of acinic cell carcinoma of the salivary glands were evaluated retrospectively with respect to histological and clinical data. DNA content assessment was carried out in six cases by cytophotometry.

The majority of tumors were located in the parotid gland and were Stage I at presentation. There was a female predominance and the mean age at primary diagnosis was 51.2 years for females and 41.0 for males. The solid-acinar cell pattern was the most frequently observed and the tumors were 'diploid' in all the six cases studied. Surgery was the therapeutic modality in all cases (enucleation in seven, superficial parotidectomy in three and total parotidectomy in five) and, in four of them, was complemented with radiotherapy. The clinical course was characterized by recurrence in 10 cases, metastases occurred in three patients and one patient died of the tumor. Of the seven recurrent cases, six were treated by enucleation and one by superficial parotidectomy. The histological pattern showed no correlation with the clinical course or DNA content. Acinic cell carcinoma has a significant morbidity with a high recurrence rate which seems to be largely influenced by the type of surgery employed.

Wide surgical excision of the neoplasia, which includes total parotidectomy in the parotid cases, is recommended in order to reduce the frequency of recurrence of the tumor.

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DeMay RM. The Art and Science of Cytopathology. Volume 1 and 2. ASCP Press. 1996.
Weedon D. Weedon's Skin Pathology Second Edition. Churchill Livingstone. 2002
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Last Updated June 19, 2008

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